Splice

This is oficially the worst film ever. The entire plot boils down to this:

Adrien Brody and Sarah Polley are lovers/scientists who splice (hey, that's the name of the film!) animal and human DNA, resulting in a creature called Dren (hey, that's 'nerd' backwards!). Brody fucks Dren, she dies, then comes back to life as a male (somehow), and rapes Polley, who becomes preggers.

It therefore should have been 5 minutes long, not 2 hours. Fuck.